Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280077 | 0.88 | HSD11B1 (0.43) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5767929 | 0.83 | KDM4E (0.42) | RAB9AKDM4EMAPK14NT5EPIM1 | |
| SCHEMBL5766205 | 0.81 | HSD11B1 (0.41) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5763633 | 0.77 | MAPK14 (0.50) | MAPK14 | |
| SCHEMBL5763347 | 0.74 | HSD11B1 (0.41) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5775392 | 0.70 | NT5E (0.41) | HSD11B1MAPK14NT5EPIM1 | |
| SCHEMBL13385743 | 0.69 | HSD11B1 (0.53) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4072097 | 0.69 | HSD11B1 (0.49) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15007237 | 0.69 | HSD11B1 (0.52) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4825071 | 0.69 | ALDH1A1 (0.48) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |