Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 5/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833166 | 0.86 | ABCC9 (0.54) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL5766461 | 0.84 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL87317 | 0.78 | ALDH1A1 (0.83) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL7829727 | 0.78 | ABCC9 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7829722 | 0.78 | ABCC9 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7832140 | 0.78 | MAPK14 (0.56) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL7833285 | 0.76 | ABCC9 (0.49) | PDK1PDK2PDK3PDK4MAPK14 | |
| SCHEMBL7829732 | 0.75 | ABCC9 (0.58) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL8796551 | 0.74 | PDK1 (0.47) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL5766822 | 0.72 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |