Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 7/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.54 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.54 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7832140 | 0.91 | MAPK14 (0.56) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5763615 | 0.86 | PDK1 (0.54) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL7833285 | 0.85 | ABCC9 (0.49) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7829732 | 0.84 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7829722 | 0.83 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7829727 | 0.83 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7830325 | 0.83 | PDK1 (0.50) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL7833294 | 0.82 | NPC1 (0.55) | ABCC9ABCC8KCNJ11KCNJ8RAB9A | |
| SCHEMBL7832756 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7832380 | 0.80 | ABCC9 (0.67) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |