Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HCN1 | O60741 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20446611 | 0.81 | SLC6A3 (0.40) | GAA | |
| SCHEMBL5736474 | 0.80 | OPRM1 (0.36) | OPRM1OPRL1HTTKCNH2ALDH1A1 | |
| SCHEMBL5734399 | 0.79 | HSD11B1 (0.41) | HDAC4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5735070 | 0.75 | HDAC4 (0.44) | HDAC4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL1097860 | 0.75 | MEN1 (0.45) | HDAC4OPRM1OPRD1KCNH2ALDH1A1 | |
| SCHEMBL6273380 | 0.73 | HSD11B1 (0.41) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL3177666 | 0.73 | OPRL1 (0.43) | HDAC4OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL11971959 | 0.72 | HDAC4 (0.60) | HDAC4OPRL1P2RX7KIF11 | |
| SCHEMBL2494142 | 0.71 | SLC6A3 (0.40) | KIF11GAA | |
| SCHEMBL28721214 | 0.71 | HSD11B1 (0.44) | HDAC4OPRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |