Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 1.00 |
| ▸ | EGFR | P00533 | 14/20 | 1.00 |
| ▸ | SRC | P12931 | 11/20 | 0.84 |
| ▸ | WEE1 | P30291 | 3/20 | 0.78 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.78 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.78 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.75 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.75 |
| ▸ | ABL1 | P00519 | 6/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.75 |
| ▸ | KIT | P10721 | 2/20 | 0.74 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.73 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.73 |
| ▸ | STK10 | O94804 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763930 | 0.93 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL5764000 | 0.91 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL2242561 | 0.89 | FGFR1 (0.81) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL5762228 | 0.88 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL1249524 | 0.88 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL13498143 | 0.87 | FGFR1 (0.83) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL5762318 | 0.86 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL2083206 | 0.86 | SRC (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL2082743 | 0.86 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 | |
| SCHEMBL5764012 | 0.86 | FGFR1 (1.00) | FGFR1EGFRSRCWEE1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | claimed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | claimed |
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | disclosed |