Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 1.00 |
| ▸ | EGFR | P00533 | 13/20 | 1.00 |
| ▸ | SRC | P12931 | 11/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.77 |
| ▸ | STAT5A | P42229 | 1/20 | 0.77 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.77 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.77 |
| ▸ | ABL1 | P00519 | 7/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.74 |
| ▸ | WEE1 | P30291 | 3/20 | 0.74 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.71 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.71 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256711 | 0.87 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL30257377 | 0.87 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL29765306 | 0.87 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL29378902 | 0.87 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5764000 | 0.87 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5762228 | 0.86 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5764023 | 0.86 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5762046 | 0.85 | SRC (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5763930 | 0.85 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA | |
| SCHEMBL5762573 | 0.85 | FGFR1 (1.00) | FGFR1EGFRSRCPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | claimed |
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | disclosed |