Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017457 | 0.79 | TLR7 (0.43) | HPGDTSHRPDE4APDE4BPDE4C | |
| SCHEMBL5821050 | 0.79 | KIF11 (0.42) | HPGDTSHRHSD17B10KDM4EMAPT | |
| SCHEMBL5766296 | 0.79 | TLR7 (0.46) | HPGDTSHRHSD17B10GAAALDH1A1 | |
| SCHEMBL6515882 | 0.77 | KIF11 (0.38) | MAPTKIF11 | |
| SCHEMBL7257039 | 0.77 | PDE4A (0.56) | TSHRHSD17B10CFTRPDE4APDE4B | |
| SCHEMBL2351103 | 0.77 | PDE4A (0.56) | TSHRHSD17B10CFTRPDE4APDE4B | |
| SCHEMBL5107156 | 0.75 | MAPT (0.51) | GAAKDM4EMAPTNPSR1KIF11 | |
| SCHEMBL3838642 | 0.74 | KDM4E (0.45) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5821082 | 0.73 | KIF11 (0.55) | KIF11 | |
| SCHEMBL5764546 | 0.73 | PDE4A (0.46) | CFTRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509507-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050234080-A1 | Mitotic kinesin inhibitors | COLEMAN PAUL J | 2005-10-20 | — | — | US | disclosed |
| EP-1509507-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003099211-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234080-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIFC1 | HPGD 3420/4885TSHR 4798/4885HSD17B10 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.