Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | APRT | P07741 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765181 | 0.83 | IRAK4 (0.43) | KDM4EFGFR1SRCKMT2AGAK | |
| SCHEMBL5767404 | 0.81 | FGFR1 (0.42) | MIFFGFR1SRCGAKRIPK2 | |
| SCHEMBL5767029 | 0.81 | MIF (0.48) | MIFFGFR1SRCNTRK1FLT3 | |
| SCHEMBL5766820 | 0.80 | FGFR1 (0.54) | MIFFGFR1SRCCDK1CDK2 | |
| SCHEMBL5766356 | 0.79 | PIK3CA (0.40) | FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL5767045 | 0.78 | BRAF (0.39) | MIFKDM4EFGFR1SRCNTRK1 | |
| SCHEMBL5767448 | 0.78 | FGFR1 (0.45) | MIFFGFR1SRCCDK2 | |
| SCHEMBL5766459 | 0.78 | CYP11B2 (0.47) | HSD17B10FGFR1SRCKMT2AALDH1A1 | |
| SCHEMBL31060334 | 0.77 | FGFR1 (0.52) | FGFR1SRCGAKRIPK2ULK1 | |
| SCHEMBL5764733 | 0.76 | KDR (0.45) | FGFR1SRCNTRK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |