Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766459 | 0.86 | CYP11B2 (0.47) | PIK3CDFGFR1SRCKDRBRAF | |
| SCHEMBL5767029 | 0.85 | MIF (0.48) | FGFR1SRCKDRBRAF | |
| SCHEMBL5765733 | 0.84 | IRAK4 (0.41) | PIK3CAFGFR1MTORSRCPDGFRB | |
| SCHEMBL5767404 | 0.84 | FGFR1 (0.42) | FGFR1SRCPDGFRBPDGFRAKDR | |
| SCHEMBL5766820 | 0.84 | FGFR1 (0.54) | FGFR1SRCKDRBRAFATM | |
| SCHEMBL5767448 | 0.82 | FGFR1 (0.45) | FGFR1SRCKDRBRAFATM | |
| SCHEMBL5767045 | 0.82 | BRAF (0.39) | FGFR1SRCKDRBRAF | |
| SCHEMBL5764733 | 0.80 | KDR (0.45) | FGFR1SRCKDR | |
| SCHEMBL31060334 | 0.80 | FGFR1 (0.52) | FGFR1SRCPDGFRBPDGFRA | |
| SCHEMBL5765191 | 0.79 | MIF (0.39) | FGFR1SRCPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |