Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of N-Benzyl-4-Methoxyaniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.58 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Benzyl-4-Methoxyaniline SCHEMBL1757104 | 0.98 | HIF1A (0.69) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| SCHEMBL11192900 | 0.93 | HIF1A (0.64) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| N-Benzyl-4-Methoxyaniline SCHEMBL30398333 | 0.91 | HIF1A (0.62) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| N-Benzyl-4-Methoxyaniline SCHEMBL30398492 | 0.91 | HIF1A (0.62) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| SCHEMBL2306553 | 0.91 | HIF1A (0.74) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| Iodide SCHEMBL31325827 | 0.89 | HIF1A (0.72) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| Hydrochloric Acid SCHEMBL29937106 | 0.89 | HIF1A (0.72) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| SCHEMBL1844199 | 0.88 | MAPT (0.82) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| SCHEMBL5669873 | 0.88 | MAPT (0.82) | HIF1AMAPTGAAL3MBTL1NPC1 | |
| SCHEMBL10055019 | 0.88 | MAPT (0.82) | HIF1AMAPTGAAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1693366-A1 | Selective 5-HT 6 receptor ligands | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1149078-B1 | SELECTIVE 5-HT 6 RECEPTOR LIGANDS | UNIV VIRGINIA COMMONWEALTH (US) | 2006-03-08 | — | — | EP | disclosed |
| US-20040132800-A1 | N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor | CHEN ZHAOGEN (US) | 2004-07-08 | — | — | US | disclosed |
| US-6518297-B2 | Serotonin (5-HT) subtype 6 receptor (5-HT6); 3-(2-aminoethyl)indole derivatives; drug screening | VIRGINIA COMMONWEALTH UNIVERSITY | 2003-02-11 | — | — | US | disclosed |
| EP-1149078-A4 | SELECTIVE 5-HT 6? RECEPTOR LIGANDS | UNIV VIRGINIA COMMONWEALTH (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6489488-B2 | SEROTONIN (5-HT) SUBTYPE 6 RECEPTOR (5-HT6); 3-(2-AMINOETHYL)INDOLE DERIVATIVES; DRUG SCREENING | VIRGINIA COMMONWEALTH UNIVERSITY | 2002-12-03 | — | — | US | disclosed |
| US-20020103382-A1 | Selective 5-HT6 receptor ligands | GLENNON RICHARD A (US) | 2002-08-01 | — | — | US | disclosed |
| US-20020103383-A1 | Selective 5-HT6 receptor ligands | GLENNON RICHARD A (US) | 2002-08-01 | — | — | US | disclosed |
| US-6403808-B1 | TREATING MENTAL DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY | 2002-06-11 | — | — | US | disclosed |
| EP-1149078-A1 | SELECTIVE 5-HT 6? RECEPTOR LIGANDS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000034242-A1 | SELECTIVE 5-HT6 RECEPTOR LIGANDS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103382-A1 | Selective 5-HT6 receptor ligands | HTR6, HTR4, HTR5A | HIF1A 4730/4885MAPT 922/4885GAA 3346/4885 |
| US-20040132800-A1 | N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor | HTR6, HTR1B, HTR1A | HIF1A 3564/4885MAPT 3765/4885GAA 4258/4885 |
| US-20020103383-A1 | Selective 5-HT6 receptor ligands | HTR6, HTR4, HTR5A | HIF1A 4730/4885MAPT 922/4885GAA 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.