Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAA | Q9Y263 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065532 | 0.79 | GRIN1 (0.38) | GRIN2BESR1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL10392077 | 0.78 | ALDH1A1 (0.49) | GRIN2BESR1MAPTKDRKDM4E | |
| SCHEMBL5765600 | 0.76 | SMN1; SMN2 (0.42) | PLAAALPGESR1KDM4EHSD17B10 | |
| SCHEMBL8947167 | 0.75 | HPGD (0.50) | TRPA1MAPTHSP90AA1KDM4EHPGD | |
| SCHEMBL15114951 | 0.74 | TSHR (0.54) | TRPA1MAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL25402021 | 0.73 | ESR1 (0.61) | PLAAALPGGRIN2BESR1 | |
| SCHEMBL18968463 | 0.72 | KDM4E (0.58) | MAPTKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL22234295 | 0.72 | ESR1 (0.57) | PLAAALPGESR1KDM4EALDH1A1 | |
| SCHEMBL2315255 | 0.72 | BRD4 (0.53) | ESR1HSP90AA1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5763847 | 0.72 | NPSR1 (0.52) | MAPTKDRKDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506194-B1 | SUBSTITUTED RING-FUSED IMIDAZOLE DERIVATES: GABA sb A /sb RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2006-07-19 | — | — | EP | disclosed |
| US-6916827-B2 | Substituted ring-fused imidazole derivative: GABAA receptors ligands | NEUROGEN CORPORATION (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1506194-A1 | SUBSTITUTED RING-FUSED IMIDAZOLE DERIVATES: GABA sb A /sb RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2005-02-16 | — | — | EP | disclosed |
| US-20040014780-A1 | Substituted ring-fused imidazole derivative: GABAA receptors ligands | NEUROGEN CORPORATION | 2004-01-22 | — | — | US | disclosed |
| WO-2003097643-A1 | SUBSTITUTED RING-FUSED IMIDAZOLE DERIVATES: GABAA RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014780-A1 | Substituted ring-fused imidazole derivative: GABAA receptors ligands | GABRB1, GABRA1, GABRB3 | PLAA 4545/4885ALPG 3222/4885TRPA1 1689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.