Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16469856 | 0.80 | MYC (0.51) | BCHENOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL5026715 | 0.73 | NOTUM (0.51) | BCHEACHENOTUMKDM4EALDH1A1 | |
| SCHEMBL617743 | 0.71 | CA2 (0.44) | NOTUMMAPTALOX12NPSR1 | |
| SCHEMBL16470683 | 0.70 | MEN1 (0.50) | NOTUMKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL27992672 | 0.70 | ALDH1A1 (0.41) | BCHENOTUMALDH1A1MAPTHPGD | |
| SCHEMBL3230336 | 0.70 | BCHE (0.43) | BCHEACHENOTUMKDM4EALDH1A1 | |
| SCHEMBL11193164 | 0.70 | NOTUM (0.49) | BCHEACHENOTUMKDM4EMAPT | |
| SCHEMBL11995114 | 0.70 | SIGMAR1 (0.39) | NPC1NOTUMKDM4EALDH1A1MAPT | |
| SCHEMBL607557 | 0.70 | ALDH1A1 (0.65) | NPC1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6935721 | 0.69 | MAPT (0.43) | BCHEACHENOTUMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |