Alfadolone

Alfadolone

SCHEMBL57673

C[C@]12CC[C@@H](O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@@]3(C)CC(=O)[C@@H]12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 9/20 1.00
GABRA1 P14867 4/20 0.80
GABRB2 P47870 4/20 0.80
CYP3A4 P08684 3/20 0.80
CYP2C9 P11712 3/20 0.80
KMT2A Q03164 3/20 0.80
MEN1 O00255 2/20 0.80
GABRG2 P18507 2/20 0.80
GABRB3 P28472 2/20 0.80
GABRA2 P47869 2/20 0.80
GLA P06280 1/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
PMP22 Q01453 2/20 0.70
CYP1A2 P05177 1/20 0.70
TSHR P16473 1/20 0.70
ALDH1A1 P00352 1/20 0.70
MAPT P10636 1/20 0.70
GABRP O00591 1/20 0.55
GABRD O14764 1/20 0.55
GMNN O75496 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alfadolone SCHEMBL2512102 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL14525649 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL30555809 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL17223283 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL2512103 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL20075616 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL24023700 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL28333104 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL21614058 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9
Alfadolone SCHEMBL750779 1.00 G6PD (1.00) G6PDGABRA1GABRB2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 356 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2916846-B1 NEUROACTIVE STEROIDS AND THEIR USE TO FACILITATE NEUROPROTECTION DRAWBRIDGE PHARMACEUTICALS PTY LTD (AU) 2025-09-17 EP claimed
CN-119174771-A Neuroactive steroid self-microemulsifying composition and preparation method and application thereof 北京华睿鼎信科技有限公司 2024-12-24 CN claimed
CN-118873539-A Neuroactive steroid solid dispersion, solid dispersion composition, preparation method and application thereof, and medicine containing solid dispersion 北京华睿鼎信科技有限公司 2024-11-01 CN claimed
CN-116267014-A Cyclic deuterated gaboxadol and its use for treating psychotic disorders CERTEGO治疗公司 2023-06-20 CN claimed
US-20230183238-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS CERTEGO ABC, LLC 2023-06-15 US claimed
EP-4153549-A2 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS Certego Therapeutics Inc. (US) 2023-03-29 EP claimed
US-11597726-B2 Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders Certego Therapeutics Inc. (US) 2023-03-07 US claimed
US-20220127261-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS CERTEGO ABC, LLC 2022-04-28 US claimed
US-20220008398-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics (US) 2022-01-13 US claimed
WO-2021236876-A2 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS Certego Therapeutics Inc. (US) 2021-11-25 WO claimed
EP-3883566-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics Inc. (US) 2021-09-29 EP claimed
US-11123332-B2 Gaboxadol for reducing risk of suicide and rapid relief of depression Certego Therapeutics Inc. (US) 2021-09-21 US claimed
US-10966965-B2 2021-04-06 US claimed
US-20200155522-A1 GABOXADOL FOR REDUCING RISK OF SUICIDE AND RAPID RELIEF OF DEPRESSION Certego Therapeutics (US) 2020-05-21 US claimed
CN-109414444-A Neuroactive steroids, compositions and uses thereof 萨奇治疗股份有限公司 2019-03-01 CN claimed
CN-102802635-A Anaesthetic formulation GOODCHILD INVEST PTY LTD 2012-11-28 CN claimed
US-8128906-B2 Stabilized uncoated particles of reversed liquid crystalline phase materials LYOTROPIC THERAPEUTICS, INC. (US) 2012-03-06 US claimed
CN-102300566-A Cutaneous application of vasoconstrictors 2011-12-28 CN claimed
US-20100303718-A1 Stabilized Uncoated Particles of Reversed Liquid Crystalline Phase Materials ANDERSON DAVID 2010-12-02 US claimed
CN-1703199-A Aggregate with enhanced deformability comprising at least three amphiphiles for improved transport through a semi-permeable barrier and use of non-invasive drugs in vivo, in particular through the skin IDEA AG (DE) 2005-11-30 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183238-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS GABRD, GABRA6, GABRA3 G6PD 2073/4885GABRA1 8/4885GABRB2 14/4885
US-20220127261-A1 RING DEUTERATED GABOXADOL AND ITS USE FOR THE TREATMENT OF PSYCHIATRIC DISORDERS GABRD, GABRA6, GABRA3 G6PD 2073/4885GABRA1 8/4885GABRB2 14/4885
US-11597726-B2 Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders GABRD, GABRA6, GABRA3 G6PD 2073/4885GABRA1 8/4885GABRB2 14/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.