Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | SORD | Q00796 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767222 | 0.91 | LMNA (0.36) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL5765295 | 0.90 | GPR119 (0.44) | GPR119KDM4EKMT2AMEN1 | |
| SCHEMBL5763519 | 0.77 | GPR119 (0.44) | GPR119KDM4E | |
| SCHEMBL3936447 | 0.75 | KDM4E (0.56) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL3937231 | 0.73 | MMP13 (0.44) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL3943555 | 0.72 | MMP13 (0.48) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL3942361 | 0.70 | MMP13 (0.40) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL3934572 | 0.70 | MMP13 (0.46) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL13940831 | 0.70 | MMP13 (0.46) | LMNAGPR119KCNH2MMP13MMP14 | |
| SCHEMBL4720180 | 0.68 | GPR119 (0.46) | GPR119MMP13ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644340-A1 | N-{'4-SUBSTITUTED PIPERAZINE-1-SULFONYLMETHYL]ALKYL}-N-HYDROXYFORMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005000822-A1 | N-{‘4-SUBSTITUTED PIPERAZINE-1-SULFONYLMETHYL!ALKYL}-N-HYDROXYFOMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-06 | — | — | WO | disclosed |