Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773725 | 0.89 | MAPK14 (0.42) | MAPK14CYP3A4GAAMAPTMAPK1 | |
| SCHEMBL5774512 | 0.89 | ALDH1A1 (0.40) | MAPK14GAAMAPTMAPK1KDM4E | |
| SCHEMBL5770827 | 0.84 | TP53 (0.48) | MAPK14CYP3A4GAAMAPTMEN1 | |
| SCHEMBL5773732 | 0.83 | KDM4E (0.38) | MAPK14CYP3A4RXFP1GAAMAPT | |
| SCHEMBL5774393 | 0.81 | MAPK14 (0.38) | MAPK14CYP3A4 | |
| SCHEMBL5768943 | 0.80 | ALDH1A1 (0.47) | MAPK14GAAMAPTKDM4EMEN1 | |
| SCHEMBL5767550 | 0.80 | MAPK14 (0.38) | MAPK14CYP3A4 | |
| SCHEMBL5769574 | 0.80 | PI4KB (0.36) | MAPK14CYP3A4 | |
| SCHEMBL5770367 | 0.78 | MAPK14 (0.41) | MAPK14CYP3A4GAAMEN1CYP2D6 | |
| SCHEMBL18058953 | 0.75 | THRB (0.50) | MAPK14CYP3A4RXFP1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |