Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773725 | 0.80 | MAPK14 (0.42) | MAPK14CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL5773732 | 0.80 | KDM4E (0.38) | MAPK14KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5774512 | 0.79 | ALDH1A1 (0.40) | MAPK14PI4KBKMT2ACYP2C19GAA | |
| SCHEMBL5770827 | 0.79 | TP53 (0.48) | MAPK14PI4KBKMT2ACYP2D6CYP2C9 | |
| SCHEMBL5773723 | 0.78 | MAPK14 (0.41) | MAPK14KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5767550 | 0.78 | MAPK14 (0.38) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5769574 | 0.78 | PI4KB (0.36) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5772161 | 0.77 | PI4KB (0.39) | MAPK14PI4KBKMT2ACYP2C9CYP2C19 | |
| SCHEMBL5771480 | 0.77 | SSTR5 (0.47) | KMT2ALMNAHTTMEN1 | |
| SCHEMBL18058953 | 0.73 | THRB (0.50) | MAPK14PI4KBKMT2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |