Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.31 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569394 | 0.80 | TSHR (0.45) | PRKCAHTT | |
| Trifluoroacetic Acid SCHEMBL28068720 | 0.79 | TSHR (0.41) | PRKCA | |
| SCHEMBL22592233 | 0.78 | PRKCA (0.38) | PRKCAHTT | |
| SCHEMBL13737582 | 0.78 | MAPT (0.41) | PRKCAHTT | |
| SCHEMBL2551899 | 0.78 | PRKCA (0.35) | GABRR1CYP1A2PRKCAFOLH1NAALAD2 | |
| SCHEMBL14195308 | 0.78 | HMGCR (0.35) | GABRR1CYP1A2PRKCAFOLH1NAALAD2 | |
| SCHEMBL31648950 | 0.77 | MAPT (0.32) | FOLH1HTT | |
| SCHEMBL783663 | 0.77 | PRKCA (0.33) | PRKCAHTT | |
| SCHEMBL13730795 | 0.77 | PGK1 (0.42) | HTT | |
| SCHEMBL4170335 | 0.77 | PRKCA (0.33) | PRKCAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732893-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | Pfizer Japan, Inc. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092858-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | PFIZER JAPAN INC. (JP) | 2005-10-06 | — | — | WO | disclosed |