Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838070 | 0.95 | RXRA (0.50) | FFAR1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL29718989 | 0.95 | RXRA (0.50) | FFAR1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL4007916 | 0.83 | FFAR1 (0.58) | FFAR1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL30201250 | 0.82 | ALDH1A1 (0.52) | FFAR1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL1775542 | 0.82 | ALDH1A1 (0.52) | FFAR1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL31434971 | 0.81 | DAO (0.46) | MRGPRX4P2RX7DAOALDH1A1KCNJ5 | |
| Trifluoroacetic Acid SCHEMBL34475312 | 0.80 | FFAR1 (0.52) | FFAR1ALDH1A1KCNJ5KCNJ3FFAR4 | |
| SCHEMBL3135089 | 0.78 | RXRA (0.53) | RXRARXRBRXRGALDH1A1PSEN1 | |
| SCHEMBL5769360 | 0.78 | P2RX7 (0.42) | FFAR1MRGPRX4P2RX7DAOALDH1A1 | |
| SCHEMBL835012 | 0.77 | MAPT (0.51) | MRGPRX4P2RX7DAOALDH1A1KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687306-A1 | BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049613-A1 | BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME LIMITED (GB) | 2005-06-02 | — | — | WO | disclosed |