SCHEMBL577111

SCHEMBL577111

COc1nc(OC)c(C)cc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 2/20 0.42
ALDH1A1 P00352 3/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 1/20 0.40
POLB P06746 3/20 0.39
SQOR Q9Y6N5 1/20 0.36
MAPT P10636 2/20 0.34
KMT2A Q03164 2/20 0.33
HTT P42858 1/20 0.33
NQO2 P16083 4/20 0.32
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
G6PD P11413 1/20 0.32
PKM P14618 1/20 0.32
RAB9A P51151 1/20 0.32
CRHR1 P34998 1/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
GAA P10253 1/20 0.32
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15339519 0.87 RECQL (0.38) RECQLALDH1A1CYP1A2CYP2C19POLB
SCHEMBL8004058 0.83 POLB (0.38) RECQLALDH1A1CYP1A2POLBSQOR
SCHEMBL25010451 0.83 PIK3CA (0.36) RECQLALDH1A1CYP1A2CYP2C19POLB
SCHEMBL21372397 0.76 CYP3A4 (0.37) RECQLALDH1A1POLBMAPTKMT2A
SCHEMBL14478701 0.76 NQO2 (0.37) RECQLALDH1A1POLBSQORMAPT
SCHEMBL31345511 0.76 PIK3CA (0.37) RECQLALDH1A1POLBMAPTHTT
SCHEMBL1674658 0.76 PIK3CA (0.37) RECQLALDH1A1POLBMAPTHTT
SCHEMBL26287691 0.74 PGK1 (0.38) RECQLALDH1A1POLBMAPTKMT2A
SCHEMBL167603 0.73 TDP1 (0.55) ALDH1A1CYP1A2POLBMAPTKMT2A
SCHEMBL22595837 0.73 POLB (0.35) RECQLPOLBCRHR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547315-B1 COLOURING COMPOSITION FOR KERATIN FIBRES KAO GERMANY GMBH (DE) 2017-07-05 EP claimed
US-8523956-B2 Colouring composition for keratin fibres KAO GERMANY GMBH (DE) 2013-09-03 US claimed
EP-2547315-A1 COLOURING COMPOSITION FOR KERATIN FIBRES Kao Germany GmbH (DE) 2013-01-23 EP claimed
US-20130000056-A1 COLOURING COMPOSITION FOR KERATIN FIBRES KAO GERMANY GMBH (DE) 2013-01-03 US claimed
WO-2011113452-A1 COLOURING COMPOSITION FOR KERATIN FIBRES KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) 2011-09-22 WO claimed
EP-2226065-A2 Colouring composition for keratin fibres KPSS-Kao Professional Salon Services GmbH (DE) 2010-09-08 EP claimed
EP-2658511-B1 DYEING COMPOSITION FOR KERATIN FIBERS KAO GERMANY GMBH (DE) 2018-04-04 EP disclosed
EP-2547315-B1 COLOURING COMPOSITION FOR KERATIN FIBRES KAO GERMANY GMBH (DE) 2017-07-05 EP disclosed
EP-2563322-B1 PROCESS FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO WASHING KAO GERMANY GMBH (DE) 2016-10-05 EP disclosed
US-8709102-B2 Dyeing composition for keratin fibers KAO GERMANY GMBH (DE) 2014-04-29 US disclosed
US-8608809-B2 Stable oxidative colouring composition for keratin fibres KAO GERMANY GMBH (DE) 2013-12-17 US disclosed
US-8579993-B2 Use of dyestuffs for dyeing keratin fibers and compositions comprising the dyestuffs KAO GERMANY GMBH (DE) 2013-11-12 US disclosed
EP-2658511-A1 DYEING COMPOSITION FOR KERATIN FIBERS Kao Germany GmbH (DE) 2013-11-06 EP disclosed
EP-2422762-A1 Stable oxidative colouring composition for keratin fibers KPSS-Kao Professional Salon Services GmbH (DE) 2012-02-29 EP disclosed
EP-2417964-A1 Method of decreasing cysteic acid formation in keratin fibres KPSS-Kao Professional Salon Services GmbH (DE) 2012-02-15 EP disclosed
WO-2011134848-A2 USE OF AN AMINE AND/OR A QUATERNARY AMMONIUM COMPOUND FOR PROTECTING COLOUR OF ARTIFICIALLY COLOURED HAIR WITH RESPECT TO THE WASHING AND PROCESS THEREFORE KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) 2011-11-03 WO disclosed
EP-2382962-A1 Use of an amine and/or a quaternary ammonium compound for protecting colour of artificially coloured hair with respect to the washing and process therefore KPSS-Kao Professional Salon Services GmbH (DE) 2011-11-02 EP disclosed
WO-2011113452-A1 COLOURING COMPOSITION FOR KERATIN FIBRES KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) 2011-09-22 WO disclosed
EP-2226065-A2 Colouring composition for keratin fibres KPSS-Kao Professional Salon Services GmbH (DE) 2010-09-08 EP disclosed
CN-1578771-A Developer components and their use for dyeing keratinic fibers HENKEL KGAA (DE) 2005-02-09 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130000056-A1 COLOURING COMPOSITION FOR KERATIN FIBRES KRT18, MDN1, CUTA RECQL 2886/4885ALDH1A1 282/4885CYP1A2 244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.