SCHEMBL5771112

SCHEMBL5771112

CCN(CC)CCc1cc2c(O)cccc2[nH]1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 4/20 0.51
HTR2A P28223 3/20 0.46
HTR2C P28335 2/20 0.46
HTR6 P50406 1/20 0.46
HTR1D P28221 1/20 0.42
DAO P14920 1/20 0.39
DDO Q99489 1/20 0.39
MTNR1A P48039 2/20 0.39
MTNR1B P49286 2/20 0.39
CHEK1 O14757 1/20 0.38
PIM1 P11309 1/20 0.38
IDO1 P14902 1/20 0.38
LTK P29376 1/20 0.38
LIMK1 P53667 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
EGFR P00533 1/20 0.37
CTSV O60911 1/20 0.37
CTSL P07711 1/20 0.37
MPO P05164 2/20 0.36
HRH4 Q9H3N8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8088130 0.83 CTSV (0.44) DAODDOMTNR1AMTNR1BIDO1
SCHEMBL5769848 0.79 DAO (0.50) DAODDOMTNR1AMTNR1BIDO1
SCHEMBL30120739 0.76 HTR2C (0.45) HTR2AHTR2CHTR6HTR1DDAO
SCHEMBL5768535 0.74 RHEB (0.51) DAODDOIDO1HRH4IMPDH2
SCHEMBL4653410 0.74 GPR84 (0.50) DAOIDO1IMPDH2IMPDH1
SCHEMBL28352953 0.73 IMPDH2 (0.43) DAODDOMTNR1AMTNR1BIDO1
SCHEMBL9587971 0.72 ASH1L (0.44) DAODDOMTNR1AMTNR1BIDO1
SCHEMBL9534359 0.69 KDM4E (0.46) DAODDOMTNR1AMTNR1BIDO1
SCHEMBL9587954 0.69 SMN1; SMN2 (0.50) DAODDOMTNR1AMTNR1BCHEK1
SCHEMBL5771313 0.68 GRIN2D (0.49) DAODDOMTNR1AMTNR1BIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1509515-A4 SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF CYTOVIA INC (US) 2006-07-05 EP disclosed
EP-1509515-A2 SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF Cytovia, Inc. (US) 2005-03-02 EP disclosed
WO-2003097806-A2 SUBSTITUTED 4-ARYL-4H-PYRROLO[2,3-H]CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF CYTOVIA, INC. (US) 2003-11-27 WO disclosed