Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965838 | 0.76 | KMT2A (0.47) | HPGDKMT2AMEN1LMNANPC1 | |
| SCHEMBL18544668 | 0.74 | LMNA (0.50) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL4574791 | 0.74 | MEN1 (0.45) | HPGDUSP2KMT2AMEN1NPC1 | |
| SCHEMBL4574595 | 0.70 | LMNA (0.46) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL19036565 | 0.67 | CYP3A4 (0.42) | KMT2AGLA | |
| SCHEMBL9824663 | 0.67 | CLCN2 (0.45) | KMT2AMEN1LMNA | |
| SCHEMBL4574011 | 0.67 | SMN1; SMN2 (0.50) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL7182897 | 0.66 | HPGD (0.50) | HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1943292 | 0.66 | RAB9A (0.51) | HPGDKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL23021674 | 0.64 | HPGD (0.61) | HPGDUSP2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |