Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774131 | 0.90 | LMNA (0.53) | KDM4EMAPTGRM5JAK2JAK3 | |
| SCHEMBL5770812 | 0.88 | MAPT (0.48) | KDM4EMAPTJAK2JAK3LMNA | |
| SCHEMBL5774953 | 0.84 | LMNA (0.46) | KDM4EMAPTJAK2JAK3LMNA | |
| SCHEMBL6646981 | 0.83 | KDM4E (0.47) | KDM4EMAPTGRM5LMNA | |
| SCHEMBL5775847 | 0.82 | RAB9A (0.52) | KDM4EMAPTJAK1LMNA | |
| SCHEMBL5777381 | 0.82 | GRM5 (0.46) | KDM4EMAPTGRM5 | |
| SCHEMBL6743436 | 0.80 | LMNA (0.44) | KDM4EMAPTJAK2JAK3LMNA | |
| SCHEMBL5774009 | 0.80 | JAK2 (0.48) | KDM4EMAPTJAK2JAK1LMNA | |
| SCHEMBL5776616 | 0.78 | MAPT (0.45) | KDM4EMAPTJAK2JAK1 | |
| SCHEMBL5775294 | 0.76 | KMT2A (0.47) | KDM4EMAPTJAK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436292-B1 | 5-METHOXY-8-ARYL-¬1,2,4|TRIAZOLO¬1,5-A|PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-6693116-B2 | 8-PHENYL-(1,2,4)TRIAZOLO(1,5-A)PYRIDIN-2-YL)-BENZAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2004-02-17 | — | — | US | disclosed |