Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774953 | 0.95 | LMNA (0.46) | LMNAADCY1JAK2MAPTF2 | |
| SCHEMBL5770812 | 0.90 | MAPT (0.48) | LMNAJAK2MAPTF2KMT2A | |
| SCHEMBL5774131 | 0.90 | LMNA (0.53) | LMNAJAK2MAPTF2KMT2A | |
| SCHEMBL5776616 | 0.83 | MAPT (0.45) | JAK2MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5774009 | 0.83 | JAK2 (0.48) | LMNAADCY1JAK2MAPTKMT2A | |
| SCHEMBL5775294 | 0.82 | KMT2A (0.47) | LMNAMAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5771367 | 0.80 | KDM4E (0.47) | LMNAJAK2MAPTJAK3KDM4E | |
| SCHEMBL6646981 | 0.79 | KDM4E (0.47) | LMNAMAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5775847 | 0.74 | RAB9A (0.52) | LMNAMAPTKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5777381 | 0.74 | GRM5 (0.46) | MAPTKMT2ARAB9ANPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693116-B2 | 8-PHENYL-(1,2,4)TRIAZOLO(1,5-A)PYRIDIN-2-YL)-BENZAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2004-02-17 | — | — | US | disclosed |