Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775847 | 0.90 | RAB9A (0.52) | MEN1KMT2AKCNK3KCNK9POLB | |
| SCHEMBL6646981 | 0.89 | KDM4E (0.47) | GRM5MEN1KMT2AKCNK3POLB | |
| SCHEMBL6647054 | 0.89 | TDP2 (0.52) | GRM5POLBMAPTKDM4EHPGD | |
| SCHEMBL5770812 | 0.84 | MAPT (0.48) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL5774131 | 0.84 | LMNA (0.53) | GRM5KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL5771367 | 0.82 | KDM4E (0.47) | GRM5MAPTKDM4E | |
| SCHEMBL5774953 | 0.78 | LMNA (0.46) | KMT2AMAPTKDM4EALDH1A1GAA | |
| SCHEMBL5774009 | 0.78 | JAK2 (0.48) | MEN1KMT2APOLBMAPTKDM4E | |
| SCHEMBL5776616 | 0.78 | MAPT (0.45) | POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL6743436 | 0.74 | LMNA (0.44) | KMT2AMAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436292-B1 | 5-METHOXY-8-ARYL-¬1,2,4|TRIAZOLO¬1,5-A|PYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-6693116-B2 | 8-PHENYL-(1,2,4)TRIAZOLO(1,5-A)PYRIDIN-2-YL)-BENZAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2004-02-17 | — | — | US | disclosed |