Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5777028 | 0.98 | HTR2C (0.38) | TGFBR1TGFBR2HTR2CMGAMGAA | |
| SCHEMBL5772801 | 0.85 | KMO (0.36) | NPY5R | |
| SCHEMBL5772104 | 0.84 | XDH (0.41) | HTR2CCDC7NPY5RSCN2AIDO1 | |
| Hydrochloric Acid SCHEMBL5778148 | 0.83 | KMO (0.34) | NPY5R | |
| Hydrochloric Acid SCHEMBL5774377 | 0.82 | HTR2C (0.41) | HTR2CCDC7NPY5RSCN2AIDO1 | |
| SCHEMBL5773678 | 0.80 | RAD51 (0.36) | HTR2CMGAMGAASIMGAM2 | |
| SCHEMBL5773374 | 0.79 | MGAM (0.45) | TGFBR1TGFBR2MGAMGAASI | |
| Hydrochloric Acid SCHEMBL5773419 | 0.78 | RAD51 (0.34) | HTR2CMAPKAPK2 | |
| SCHEMBL5774961 | 0.77 | MGAM (0.43) | TGFBR1TGFBR2MGAMGAASI | |
| SCHEMBL5772845 | 0.74 | NPY5R (0.41) | TGFBR1TGFBR2MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |