Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11396935 | 0.97 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL8163709 | 0.87 | TSHR (0.44) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL2929533 | 0.86 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL1776614 | 0.86 | KDM4E (0.51) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL5773409 | 0.83 | MAPT (0.49) | SMN1; SMN2MAPTTSHRMEN1KMT2A | |
| SCHEMBL11395576 | 0.82 | JAK2 (0.55) | ALDH1A1SMN1; SMN2MAPTJAK2JAK3 | |
| SCHEMBL3978092 | 0.82 | JAK2 (0.55) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL20241126 | 0.81 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL2929763 | 0.81 | PTGS1 (0.54) | ALDH1A1SMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL405942 | 0.81 | TSHR (0.50) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | ALDH1A1 1045/4885SMN1; SMN2 3383/4885MAPT 4701/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | ALDH1A1 682/4885SMN1; SMN2 2449/4885MAPT 4763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.