Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 6/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31119010 | 0.82 | KMO (0.62) | KMOPLK1SMN1; SMN2CAMK2DABL1 | |
| SCHEMBL443718 | 0.82 | KMO (0.62) | KMOPLK1SMN1; SMN2CAMK2DABL1 | |
| SCHEMBL25178278 | 0.81 | MEN1 (0.50) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL2349505 | 0.81 | KMO (0.60) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL1466904 | 0.79 | CAMK2D (0.58) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL2350651 | 0.79 | KMO (0.59) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL823885 | 0.79 | HSD17B1 (0.55) | KMOPLK1HSD17B1HSD17B2CYP19A1 | |
| SCHEMBL10042675 | 0.79 | MEN1 (0.48) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL30039418 | 0.79 | KMO (0.59) | KMOPLK1MEN1KMT2AALDH1A1 | |
| SCHEMBL3754295 | 0.79 | ALDH1A1 (0.46) | KMOPLK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701944-A2 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066139-A2 | 2-(AMINO-SUBSTITUTED)-4-ARYL PYRAMIDINES AND RELATED COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-07-21 | — | — | WO | disclosed |