Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31024266 | 1.00 | MEN1 (0.39) | MEN1KMT2APDE3BPDE3APDE2A | |
| SCHEMBL31569501 | 0.83 | MEN1 (0.37) | MEN1KMT2ATYMSTNFATM | |
| SCHEMBL5508549 | 0.80 | MEN1 (0.40) | MEN1KMT2APDE3BPDE3ATNF | |
| SCHEMBL3711999 | 0.76 | DAO (0.37) | PDE3BPDE3APDE2AP2RY12KDM4E | |
| SCHEMBL353027 | 0.75 | ALDH1A1 (0.41) | MEN1KMT2APDE3BPDE3APDE2A | |
| SCHEMBL24113220 | 0.72 | MEN1 (0.41) | MEN1KMT2APDE3BPDE3AKDM4E | |
| SCHEMBL2541923 | 0.72 | FABP6 (0.46) | MEN1KMT2APDE3BPDE3APDE2A | |
| SCHEMBL22349154 | 0.72 | KDM4E (0.43) | PDE3BPDE3APDE2AP2RY12KDM4E | |
| SCHEMBL9144166 | 0.72 | PDE3B (0.36) | PDE3BPDE3APDE2AP2RY12KDM4E | |
| SCHEMBL4069922 | 0.71 | SMN1; SMN2 (0.40) | MEN1KMT2APDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | disclosed |
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | PFIZER INC. | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | DPYD, PAH, DHPS | MEN1 2745/4885KMT2A 4397/4885PDE3B 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.