Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128774 | 0.89 | NPSR1 (0.37) | MEN1KMT2APARP1NPSR1NPC1 | |
| SCHEMBL6759198 | 0.85 | ADORA3 (0.40) | PARP1NPSR1NPC1ALDH1A1HPGD | |
| SCHEMBL9502744 | 0.84 | NPSR1 (0.53) | MEN1KMT2APARP1NPSR1NPC1 | |
| SCHEMBL24113220 | 0.81 | MEN1 (0.41) | MEN1KMT2APARP1NPSR1NPC1 | |
| SCHEMBL31024266 | 0.80 | MEN1 (0.39) | MEN1KMT2ATNFATMNOD2 | |
| SCHEMBL5772321 | 0.80 | MEN1 (0.39) | MEN1KMT2ATNFATMNOD2 | |
| SCHEMBL31569089 | 0.78 | MEN1 (0.40) | MEN1KMT2APARP1NPSR1ELANE | |
| SCHEMBL6139156 | 0.77 | PARP1 (0.41) | PARP1NPSR1NPC1ALDH1A1HPGD | |
| SCHEMBL31033488 | 0.76 | PARP1 (0.56) | MEN1KMT2APARP1NPSR1NPC1 | |
| SCHEMBL353892 | 0.76 | PARP1 (0.56) | MEN1KMT2APARP1NPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846409-A1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES | Pfizer Limited (GB) | 2007-10-24 | — | — | EP | disclosed |
| EP-1671972-A1 | Octahydropyrrolo[3,4-c]pyrrole derivatives | Pfizer Limited (GB) | 2006-06-21 | — | — | EP | disclosed |
| WO-2006056848-A1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES | PFIZER LIMITED (GB) | 2006-06-01 | — | — | WO | disclosed |
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | PFIZER INC. | 2006-05-25 | — | — | US | disclosed |
| EP-0517476-B1 | Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof | SUMITOMO CHEMICAL CO (JP) | 1997-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111416-A1 | Octahydropyrrolo[3,4-C]pyrrole derivatives | DPYD, PAH, DHPS | MEN1 2745/4885KMT2A 4397/4885PARP1 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.