Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5772584 | 0.99 | MAPT (0.32) | MAPTMAPK1KDM1AMAOB | |
| SCHEMBL5771685 | 0.90 | MEN1 (0.33) | MAPTKDM1A | |
| SCHEMBL5774723 | 0.89 | ALDH1A1 (0.32) | MAPT | |
| SCHEMBL5771433 | 0.88 | NPY5R (0.32) | MAPT | |
| Hydrochloric Acid SCHEMBL5772599 | 0.88 | ALDH1A1 (0.32) | MAPT | |
| Hydrochloric Acid SCHEMBL5775499 | 0.87 | HPGDS (0.32) | — | |
| SCHEMBL5771660 | 0.87 | SLC9A1 (0.32) | KDM1AMAOB | |
| SCHEMBL5773252 | 0.87 | HPGDS (0.34) | — | |
| Hydrochloric Acid SCHEMBL5775416 | 0.86 | NPY5R (0.31) | — | |
| SCHEMBL5773116 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |