Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777884 | 0.94 | KDM1A (0.48) | KDM1AMAPTHTTCYP2D6CYP2C19 | |
| SCHEMBL5772672 | 0.91 | HTR2A (0.50) | KDM1AMAPTHTTCYP2D6CYP2C19 | |
| SCHEMBL5745434 | 0.86 | CYP2D6 (0.50) | MAPTHTTCYP2D6CYP2C19L3MBTL1 | |
| SCHEMBL5774116 | 0.83 | HRH3 (0.53) | MAPTCYP2D6CYP2C19L3MBTL1KMT2A | |
| SCHEMBL5776994 | 0.83 | HTT (0.52) | KDM1AMAPTHTTCYP2C19L3MBTL1 | |
| SCHEMBL5775529 | 0.82 | KDM1A (0.49) | KDM1AMAPTHTTCYP2C19LMNA | |
| SCHEMBL5770337 | 0.81 | KDM1A (0.48) | KDM1AMAPTHTTCYP2C19LMNA | |
| SCHEMBL5773781 | 0.81 | HTT (0.50) | KDM1AMAPTHTTCYP2C19CHEK1 | |
| SCHEMBL5822008 | 0.80 | G6PD (0.48) | KDM1AMAPTHTTCYP2C19HPGD | |
| SCHEMBL5772233 | 0.80 | KDM1A (0.49) | KDM1AMAPTHTTCYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |