Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772950 | 0.89 | G6PD (0.49) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5776994 | 0.86 | HTT (0.52) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL11384305 | 0.85 | HTR1B (0.52) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5822008 | 0.85 | G6PD (0.48) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11376441 | 0.84 | HTR1B (0.51) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5772233 | 0.83 | KDM1A (0.49) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5775529 | 0.83 | KDM1A (0.49) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5770337 | 0.82 | KDM1A (0.48) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5777884 | 0.82 | KDM1A (0.48) | HTTKDM1AMAPTKDM4EALDH1A1 | |
| SCHEMBL5772672 | 0.81 | HTR2A (0.50) | HTTKDM1AMAPTKDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |