Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11426669 | 0.85 | IDO1 (0.41) | MAPK1HIF1ALMNAHPGDIDO1 | |
| SCHEMBL1046241 | 0.82 | ADRB2 (0.46) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL9180201 | 0.78 | ACHE (0.48) | TDP1IDO1SMN1; SMN2 | |
| SCHEMBL2632879 | 0.78 | ADRB2 (0.52) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL14705838 | 0.78 | ADRB2 (0.52) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL2931566 | 0.78 | ADRB2 (0.52) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL10192291 | 0.78 | ADRB2 (0.52) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL24616595 | 0.76 | ADRB2 (0.50) | ADRB2C3AR1TSHRMAPK1HIF1A | |
| SCHEMBL21286098 | 0.76 | TAAR1 (0.60) | ADRB2C3AR1TSHRSLC6A3SLC6A2 | |
| SCHEMBL21286089 | 0.76 | TAAR1 (0.60) | ADRB2C3AR1TSHRSLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | claimed |
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5502054-A | LARVACIDES FOR INSECTS SUCH AS TOBACCO BUDWORM | FMC CORPORATION (US) | 1996-03-26 | — | — | US | disclosed |
| US-4029676-A | ANTIADRENERGIC, ANTIFIBRILLATORY | E. R. SQUIBB & SONS, INC. (US) | 1977-06-14 | — | — | US | disclosed |