Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775854 | 0.92 | DRD2 (0.54) | ADRA1AHTR1ADRD2DRD3DRD1 | |
| SCHEMBL5777128 | 0.89 | DRD2 (0.53) | ADRA1AHTR1ADRD2DRD3DRD1 | |
| SCHEMBL5773754 | 0.88 | ADRA1B (0.49) | ADRA1BADRA1AADRA1DHTR1ADRD3 | |
| SCHEMBL5778134 | 0.86 | HTR1A (0.53) | ADRA1BADRA1AADRA1DHTR1ADRD2 | |
| SCHEMBL5772576 | 0.85 | HTR1A (0.48) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL5777048 | 0.85 | DRD2 (0.56) | HTR1ADRD2DRD3DRD1HTR2A | |
| SCHEMBL5772832 | 0.85 | SIGMAR1 (0.53) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL5796556 | 0.84 | DRD2 (0.53) | LMNAADRA1BADRA1AADRA1DHTR1A | |
| SCHEMBL5772457 | 0.84 | SIGMAR1 (0.52) | HTR1ADRD2DRD3HTR2AHTR7 | |
| SCHEMBL5772229 | 0.83 | SIGMAR1 (0.52) | KDM4EHTR1ADRD2DRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |