Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173494 | 0.95 | ATM (0.40) | ATMNR1I3HDAC3HDAC1HDAC2 | |
| SCHEMBL2762684 | 0.83 | ATM (0.41) | ATMNR1I3HDAC3HDAC1HDAC2 | |
| SCHEMBL27645340 | 0.79 | ATM (0.42) | ATMCA1CA2CYP1A2ADRA2A | |
| SCHEMBL2763052 | 0.78 | MMP8 (0.38) | ATMNR1I3MMP3MMP8 | |
| SCHEMBL3167857 | 0.77 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL13376023 | 0.76 | MMP8 (0.38) | ATMNR1I3DRD2MMP3MMP8 | |
| SCHEMBL3165587 | 0.76 | ATM (0.38) | ATMNR1I3PRMT5WDR77CYP17A1 | |
| SCHEMBL17827825 | 0.72 | SIRT2 (0.40) | NR1I3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL17827852 | 0.70 | NR1I3 (0.41) | NR1I3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1114945 | 0.69 | RAB9A (0.56) | NR1I3CYP17A1CA1CYP1A2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654257-A1 | AMINOPYRONES AND THEIR USE AS ATM INHIBITORS | Kudos Pharmaceuticals Limited (GB) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016919-A1 | AMINOPYRONES AND THEIR USE AS ATM INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |