Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772950 | 0.94 | G6PD (0.49) | G6PDSLC6A4SLC6A2HRH1KDM1A | |
| SCHEMBL5773781 | 0.85 | HTT (0.50) | G6PDKDM1AHTTMAPTKCNA3 | |
| SCHEMBL5770337 | 0.83 | KDM1A (0.48) | KDM1AHTTMAPTPOLBKCNA3 | |
| SCHEMBL5776994 | 0.83 | HTT (0.52) | KDM1AHTTMAPTKCNA3KDM4E | |
| SCHEMBL5775529 | 0.82 | KDM1A (0.49) | SLC6A4HRH1KDM1AHTTMAPT | |
| SCHEMBL5772233 | 0.82 | KDM1A (0.49) | KDM1AHTTMAPTKCNA3KDM4E | |
| SCHEMBL5746113 | 0.81 | MAPT (0.49) | G6PDSLC6A4SLC6A2HRH1KDM1A | |
| SCHEMBL5770520 | 0.80 | KDM1A (0.47) | KDM1AHTTMAPTHPGDHRH3 | |
| SCHEMBL5777884 | 0.79 | KDM1A (0.48) | KDM1AHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL5772672 | 0.78 | HTR2A (0.50) | KDM1AHTTMAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |