Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.47 |
| ▸ | CLPP | Q16740 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957466 | 0.91 | SIGMAR1 (0.58) | L3MBTL1SIGMAR1CLPPHTR1ADRD2 | |
| SCHEMBL5774541 | 0.80 | HTR1A (0.49) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| SCHEMBL7960754 | 0.79 | HTR1A (0.48) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL5772589 | 0.79 | HTR1A (0.48) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| SCHEMBL5773040 | 0.79 | MAPK1 (0.46) | GAAPARP1HTR1ADRD2DRD3 | |
| SCHEMBL5771879 | 0.79 | DRD2 (0.45) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL5775839 | 0.79 | HTR1A (0.45) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| SCHEMBL5774579 | 0.77 | HTR1A (0.54) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| SCHEMBL5771928 | 0.77 | DRD2 (0.43) | SIGMAR1PARP1HTR1ADRD2DRD3 | |
| SCHEMBL5772376 | 0.77 | HTR1A (0.43) | SIGMAR1PARP1HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |