Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 9/20 | 0.52 |
| ▸ | IP6K2 | Q9UHH9 | 9/20 | 0.52 |
| ▸ | IP6K3 | Q96PC2 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774464 | 1.00 | IP6K1 (0.52) | IP6K1IP6K2IP6K3ALDH1A1HTT | |
| SCHEMBL4676910 | 0.86 | IP6K1 (0.58) | IP6K1IP6K2IP6K3ALDH1A1HTT | |
| SCHEMBL15239076 | 0.83 | ALDH1A1 (0.43) | IP6K1IP6K2IP6K3ALDH1A1HTT | |
| SCHEMBL15239078 | 0.83 | ALDH1A1 (0.43) | IP6K1IP6K2IP6K3ALDH1A1HTT | |
| SCHEMBL3982046 | 0.79 | ALDH1A1 (0.46) | IP6K1ALDH1A1BRD4BRD2MAPT | |
| SCHEMBL1124487 | 0.77 | GAA (0.49) | IP6K1IP6K2IP6K3ALDH1A1GAA | |
| SCHEMBL1124489 | 0.77 | GAA (0.49) | IP6K1IP6K2IP6K3ALDH1A1GAA | |
| SCHEMBL5773258 | 0.76 | ALDH1A1 (0.49) | ALDH1A1GAALMNAMAPTKDM4E | |
| SCHEMBL5773251 | 0.76 | ALDH1A1 (0.49) | ALDH1A1GAALMNAMAPTKDM4E | |
| SCHEMBL1574 | 0.72 | IP6K1 (0.45) | IP6K1IP6K2IP6K3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | IP6K1 729/4885IP6K2 866/4885IP6K3 253/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | IP6K1 396/4885IP6K2 570/4885IP6K3 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.