Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | JUND | P17535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776632 | 0.78 | GABRA1 (0.42) | HRH1SLC18A3SIGMAR1KHKGABRA1 | |
| Hydrochloric Acid SCHEMBL5807137 | 0.75 | KDM4E (0.43) | HTR2CSLC18A3SIGMAR1KDM4EHPGD | |
| SCHEMBL5774480 | 0.74 | KDM4E (0.44) | HTR2CSLC18A3SIGMAR1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL5775248 | 0.74 | KDM4E (0.44) | POLBHTR2CSLC18A3SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL5773701 | 0.73 | KDM4E (0.47) | HTR2CSLC18A3SIGMAR1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL5776951 | 0.73 | KDM4E (0.43) | HTR2CSLC18A3SIGMAR1KDM4EHPGD | |
| SCHEMBL5776541 | 0.71 | MAPK14 (0.45) | HTR2C | |
| SCHEMBL8125046 | 0.70 | MEN1 (0.44) | HTR2CGABRA1JUNDFOSB | |
| SCHEMBL5774851 | 0.67 | MAPK14 (0.48) | HTR2CGABRA1 | |
| SCHEMBL5775115 | 0.67 | USP7 (0.41) | KDM4EHPGDSMN1; SMN2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |