Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777830 | 0.78 | SLC6A2 (0.43) | GABRA1GABRG2GABRB3KHKHRH1 | |
| Hydrochloric Acid SCHEMBL5775248 | 0.75 | KDM4E (0.44) | GABRA1GABRB2SLC18A3SIGMAR1 | |
| SCHEMBL5774480 | 0.75 | KDM4E (0.44) | GABRA1GABRB2SLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5807137 | 0.74 | KDM4E (0.43) | GABRA1GABRB2SLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5776951 | 0.74 | KDM4E (0.43) | GABRA1GABRB2SLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5773701 | 0.74 | KDM4E (0.47) | GABRA1GABRG2GABRB3GABRB2SLC18A3 | |
| SCHEMBL5776541 | 0.71 | MAPK14 (0.45) | — | |
| SCHEMBL3949876 | 0.68 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRB2HRH1 | |
| SCHEMBL5775115 | 0.68 | USP7 (0.41) | GABRA1GABRB2 | |
| SCHEMBL5774851 | 0.68 | MAPK14 (0.48) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |