Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SELL | P14151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777508 | 0.88 | ITGB3 (0.56) | ITGB3ITGA2BMAPTGAAMEN1 | |
| SCHEMBL4752320 | 0.81 | HTR6 (0.55) | ITGB3ITGA2BMAPTGAAGFER | |
| SCHEMBL4337810 | 0.79 | TRPV1 (0.53) | ITGB3ITGA2BMAPTGAAALDH1A1 | |
| SCHEMBL4334746 | 0.78 | MAOA (0.58) | ITGB3ITGA2BMAPTGAAALDH1A1 | |
| SCHEMBL16246034 | 0.78 | MAPT (0.54) | ITGB3ITGA2BMAPTGAAMEN1 | |
| SCHEMBL13735094 | 0.78 | MAPT (0.50) | ITGB3ITGA2BMAPTGAAMEN1 | |
| SCHEMBL3003205 | 0.77 | CFD (0.59) | MAPTGAACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8059186 | 0.76 | KMT2A (0.55) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL1074012 | 0.75 | MAPT (0.68) | MAPTGAAALDH1A1GFERRAB9A | |
| SCHEMBL4523190 | 0.75 | SIRT2 (0.60) | ITGB3ITGA2BMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |