Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777244 | 0.91 | P2RX7 (0.36) | HCRTR2HCRTR1HSD11B1KMT2ACHRNA1 | |
| SCHEMBL5774998 | 0.89 | HSD11B1 (0.39) | NPSR1KDM4ERXFP1HSD11B1LMNA | |
| SCHEMBL5777879 | 0.89 | ALDH1A1 (0.39) | KDM4EHCRTR2HCRTR1HSD11B1LMNA | |
| SCHEMBL5776474 | 0.87 | CNR1 (0.34) | NPSR1HCRTR2HCRTR1ALDH1A1MEN1 | |
| SCHEMBL5778953 | 0.84 | ALDH1A1 (0.41) | KDM4EHCRTR2HCRTR1HSD11B1ALDH1A1 | |
| SCHEMBL5778899 | 0.83 | THRB (0.38) | KDM4EHCRTR2HCRTR1HSD11B1ALDH1A1 | |
| SCHEMBL5776425 | 0.83 | HSD11B1 (0.39) | NPSR1HSD11B1LMNAMEN1KMT2A | |
| SCHEMBL5774115 | 0.83 | THRB (0.36) | HSD11B1LMNAALDH1A1KMT2ACHRNA1 | |
| SCHEMBL5775190 | 0.83 | GSK3B (0.35) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL5774103 | 0.82 | HTT (0.38) | NPSR1HCRTR2HCRTR1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406888-B1 | SUBSTITUTED Y-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2006-05-24 | — | — | EP | claimed |
| US-6956055-B2 | Substituted γ-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2005-10-18 | — | — | US | claimed |
| US-20040171677-A1 | Substituted gamma-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2004-09-02 | — | — | US | claimed |
| EP-1406888-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | claimed |
| WO-2003004483-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | claimed |
| EP-1406888-B1 | SUBSTITUTED Y-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2006-05-24 | — | — | EP | disclosed |
| US-6956055-B2 | Substituted γ-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2005-10-18 | — | — | US | disclosed |
| US-20040171677-A1 | Substituted gamma-lactone compounds as NMDA-antagonists | GRUNENTHAL GMBH (DE) | 2004-09-02 | — | — | US | disclosed |
| EP-1406888-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004483-A1 | SUBSTITUTED $G(G)-LACTONE COMPOUNDS SERVING AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171677-A1 | Substituted gamma-lactone compounds as NMDA-antagonists | GRIN1, GRIN3A, GRIK5 | NPSR1 114/4885KDM4E 1548/4885RXFP1 3916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.