Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774939 | 0.82 | PRNP (0.44) | CES2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL2895952 | 0.70 | GPR35 (0.62) | NPC1MAPTRAB9AKDM4E | |
| SCHEMBL20960212 | 0.69 | BCL2L1 (0.37) | NPC1MAPTRAB9A | |
| SCHEMBL12597629 | 0.69 | LIMK1 (0.47) | NPC1MAPTRAB9AHPGD | |
| SCHEMBL17149269 | 0.67 | LMNA (0.50) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL5949150 | 0.66 | RAB9A (0.49) | NPC1MAPTRAB9AFAAHALDH1A1 | |
| SCHEMBL2614668 | 0.65 | IDO1 (0.37) | MAPTRAB9A | |
| SCHEMBL12430727 | 0.65 | ROCK1 (0.46) | — | |
| SCHEMBL20893397 | 0.65 | ALDH1A1 (0.52) | NPC1TP53MAPTRAB9AALDH1A1 | |
| SCHEMBL12049627 | 0.64 | RAB9A (0.51) | NPC1TP53MAPTRAB9AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |