Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290340 | 0.83 | CES2 (0.46) | ALDH1A1MAPTPARP10HTTKMT2A | |
| SCHEMBL5567586 | 0.78 | SMN1; SMN2 (0.41) | ALDH1A1MAPTRAB9ASMN1; SMN2ATM | |
| SCHEMBL5666967 | 0.78 | SLC6A4 (0.45) | SMN1; SMN2KMT2A | |
| SCHEMBL16962611 | 0.78 | TAS1R3 (0.48) | ALDH1A1MAPTRAB9ALMNASMN1; SMN2 | |
| SCHEMBL6232499 | 0.78 | MAOB (0.42) | PARP10RAB9A | |
| SCHEMBL5774143 | 0.73 | HTT (0.40) | ALDH1A1LMNAHTTKDM4EKMT2A | |
| SCHEMBL5772527 | 0.72 | LSS (0.44) | RAB9ANPC1KMT2A | |
| SCHEMBL1652097 | 0.71 | HDAC1 (0.44) | ALDH1A1MAPTKDM4EHSD17B10KMT2A | |
| SCHEMBL9388919 | 0.70 | ALDH1A1 (0.66) | ALDH1A1MAPTPARP10RAB9ALMNA | |
| SCHEMBL10960371 | 0.70 | PARP10 (0.56) | ALDH1A1PARP10RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |