Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660244 | 0.75 | MEN1 (0.65) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL14586257 | 0.69 | MEN1 (0.65) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL10357404 | 0.68 | ALDH1A1 (0.49) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL11544508 | 0.67 | SRC (0.62) | MEN1KMT2AHPGDNPC1RAB9A | |
| SCHEMBL5067031 | 0.66 | HPGD (0.73) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4524302 | 0.66 | GAA (0.57) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL10357760 | 0.66 | POLB (0.49) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL27783694 | 0.66 | KEAP1 (0.48) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL10333611 | 0.65 | RCE1 (0.44) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL27805034 | 0.65 | LMNA (0.48) | POLBMEN1KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368345-B1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-03-22 | — | — | EP | disclosed |