Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.57 |
| ▸ | AANAT | Q16613 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CCND1 | P24385 | 2/20 | 0.54 |
| ▸ | GOT1 | P17174 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770689 | 0.92 | CDK4 (0.58) | MEN1KMT2AGSK3BGFERMTNR1A | |
| SCHEMBL7677886 | 0.83 | MEN1 (0.84) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL9117842 | 0.79 | MEN1 (0.76) | MEN1KMT2AGSK3BGFERMTNR1A | |
| SCHEMBL7852879 | 0.79 | GFER (0.84) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL9303912 | 0.78 | MEN1 (0.71) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL7849865 | 0.78 | MEN1 (0.74) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL918964 | 0.78 | MEN1 (0.78) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL918966 | 0.78 | MEN1 (0.78) | MEN1KMT2AGFERMTNR1AAANAT | |
| SCHEMBL5775645 | 0.77 | MAPT (0.45) | MEN1KMT2ACYP1A2CYP2C19CYP2D6 | |
| SCHEMBL761481 | 0.76 | MTNR1A (0.88) | MEN1KMT2AGFERMTNR1AAANAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | MEN1 2811/4885KMT2A 3907/4885GSK3B 1517/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | MEN1 2072/4885KMT2A 2906/4885GSK3B 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.