Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PPME1 | Q9Y570 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | APEH | P13798 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2457308 | 0.85 | RAPGEF4 (0.58) | RAPGEF4CA1CA2PPME1L3MBTL1 | |
| SCHEMBL4312459 | 0.78 | RAPGEF4 (0.50) | RAPGEF4CA1CA2PPME1L3MBTL1 | |
| SCHEMBL4312461 | 0.78 | RAPGEF4 (0.50) | RAPGEF4CA1CA2PPME1L3MBTL1 | |
| SCHEMBL3834757 | 0.78 | RAPGEF4 (0.65) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL3239791 | 0.75 | RAPGEF4 (0.50) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL23699019 | 0.75 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL7641128 | 0.75 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL5535689 | 0.75 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL1365792 | 0.75 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1KDM4E | |
| SCHEMBL3188642 | 0.75 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109912487-A | A method of synthesis -1 hydrogen of 1- p-toluenesulfonyl -2- vinyl-pyrroles | 山东理工大学 | 2019-06-21 | — | — | CN | claimed |
| CN-109912487-B | Method for synthesizing 1-p-toluenesulfonyl-2-vinyl-1H-pyrrole | 山东理工大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-109912487-B | Method for synthesizing 1-p-toluenesulfonyl-2-vinyl-1H-pyrrole | 山东理工大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-109912487-B | Method for synthesizing 1-p-toluenesulfonyl-2-vinyl-1H-pyrrole | 山东理工大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-109912487-A | A method of synthesis -1 hydrogen of 1- p-toluenesulfonyl -2- vinyl-pyrroles | 山东理工大学 | 2019-06-21 | — | — | CN | disclosed |
| CN-109912487-A | A method of synthesis -1 hydrogen of 1- p-toluenesulfonyl -2- vinyl-pyrroles | 山东理工大学 | 2019-06-21 | — | — | CN | disclosed |
| CN-109912487-A | A method of synthesis -1 hydrogen of 1- p-toluenesulfonyl -2- vinyl-pyrroles | 山东理工大学 | 2019-06-21 | — | — | CN | disclosed |
| US-20180002318-A1 | SYNTHESIS OF CYCLOPROPYL INDOLES AND CYCLOHEPTA[B]INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHOD OF USING THEM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-01-04 | — | — | US | disclosed |
| EP-1664043-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002318-A1 | SYNTHESIS OF CYCLOPROPYL INDOLES AND CYCLOHEPTA[B]INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHOD OF USING THEM | IDO1, IDO2, GPR119 | RAPGEF4 4186/4885CA1 1074/4885CA2 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.