Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 2/20 | 0.47 |
| ▸ | PPME1 | Q9Y570 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312459 | 1.00 | RAPGEF4 (0.50) | RAPGEF4FBP1PPME1MAPTKDM4E | |
| SCHEMBL2457308 | 0.79 | RAPGEF4 (0.58) | RAPGEF4PPME1KDM4EALDH1A1HTT | |
| SCHEMBL5776529 | 0.78 | RAPGEF4 (0.56) | RAPGEF4PPME1KDM4EALDH1A1HTT | |
| SCHEMBL22689649 | 0.77 | FBP1 (0.44) | RAPGEF4FBP1KDM4EHTTCA1 | |
| SCHEMBL22689650 | 0.77 | FBP1 (0.44) | RAPGEF4FBP1KDM4EHTTCA1 | |
| SCHEMBL14788055 | 0.75 | MAPT (0.72) | FBP1MAPTKDM4EALDH1A1HTT | |
| SCHEMBL12612442 | 0.75 | RAPGEF4 (0.56) | RAPGEF4PPME1MAPTKDM4EALDH1A1 | |
| SCHEMBL3834757 | 0.72 | RAPGEF4 (0.65) | RAPGEF4KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4316973 | 0.69 | RAPGEF4 (0.65) | RAPGEF4MAPTKDM4EHTTCA1 | |
| SCHEMBL23699019 | 0.69 | RAPGEF4 (0.61) | RAPGEF4MAPTKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9417245-B2 | Porphyrinic compounds for use in flow cytometry | NORTH CAROLINA STATE UNIVERSITY (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150153350-A1 | PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-04 | — | — | US | disclosed |
| US-8980565-B2 | Porphyrinic compounds for use in flow cytometry | NORTH CAROLINA STATE UNIVERSITY (US) | 2015-03-17 | — | — | US | disclosed |
| US-8546088-B2 | Porphyrinic compounds for use in flow cytometry | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120245508-A1 | SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-09-27 | — | — | US | disclosed |
| US-20120244551-A1 | PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-09-27 | — | — | US | disclosed |
| US-8207329-B2 | Synthesis of chlorins and phorbines with enhanced red spectral features | NORTH CAROLINA STATE UNIVERSITY (US) | 2012-06-26 | — | — | US | disclosed |
| US-8187824-B2 | Porphyrinic compounds for use in flow cytometry | NORTH CAROLINA STATE UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090227553-A1 | SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-09-10 | — | — | US | disclosed |
| US-20090075295-A1 | PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227553-A1 | SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES | CRY1, CRY2, HCCS | RAPGEF4 2368/4885FBP1 2651/4885PPME1 1396/4885 |
| US-20120245508-A1 | SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES | CRY1, CRY2, QDPR | RAPGEF4 2241/4885FBP1 2802/4885PPME1 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.