Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775785 | 0.90 | KCNH2 (0.41) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL7655147 | 0.86 | CNR2 (0.45) | ALDH1A1MAPTNPY1RCNR2TMEM97 | |
| SCHEMBL5778204 | 0.84 | HTR6 (0.42) | NPY1RCNR2 | |
| SCHEMBL4878710 | 0.76 | ACHE (0.42) | ALDH1A1MAPTGAASMN1; SMN2CKS1B | |
| SCHEMBL5774251 | 0.75 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1NPY1RCNR2 | |
| SCHEMBL1491176 | 0.72 | SMN1; SMN2 (0.51) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL3260753 | 0.72 | SMN1; SMN2 (0.51) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL8139472 | 0.70 | SMN1; SMN2 (0.54) | ALDH1A1MAPTGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL25103465 | 0.70 | SMARCA2 (0.47) | ALDH1A1MAPTCKS1BSKP1SKP2 | |
| SCHEMBL27250071 | 0.70 | CKS1B (0.47) | ALDH1A1MAPTCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200433-B1 | C-6 RING-SUBSTITUTED PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-6358946-B1 | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS, AND HYPNOSIS AGENTS; SLEEP DISORDER TREATMENT | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-03-19 | — | — | US | disclosed |