Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778204 | 0.90 | HTR6 (0.42) | CNR2NPY1RIRAK4 | |
| SCHEMBL5774251 | 0.88 | ALDH1A1 (0.41) | CNR2NPY1RHPGDTP53LMNA | |
| SCHEMBL5776881 | 0.86 | ALDH1A1 (0.43) | CNR2NPY1RALDH1A1MAPTTMEM97 | |
| SCHEMBL5775304 | 0.80 | ALDH1A1 (0.43) | NPY1RHPGDLMNAALDH1A1TSHR | |
| SCHEMBL5775785 | 0.76 | KCNH2 (0.41) | CNR2NPY1RALDH1A1MAPT | |
| SCHEMBL7419269 | 0.74 | NPY1R (0.35) | CNR2NPY1RCTNNB1IRAK4 | |
| SCHEMBL5777998 | 0.70 | ALDH1A1 (0.43) | HPGDTP53LMNAALDH1A1TSHR | |
| SCHEMBL4887137 | 0.67 | HTR1A (0.38) | ALDH1A1MAPTTMEM97SIGMAR1 | |
| SCHEMBL7806454 | 0.67 | MAPT (0.41) | CNR2NPY1RHPGDLMNAALDH1A1 | |
| SCHEMBL7978871 | 0.67 | AKT1 (0.42) | HPGDALDH1A1TSHRAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358946-B1 | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS, ANTICONVULSANTS, AND HYPNOSIS AGENTS; SLEEP DISORDER TREATMENT | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-03-19 | — | — | US | disclosed |